Research Foundation of Southern California, La Jolla
Research at the Foundation has been devoted, for over three decades,
to clarifying a number of fundamental questions in the life sciences and
mathematical physics:

● Formulation of the path-distance model has resolved the enigma of
how the genetic code formed. As anticipated, this advance helped clarify
the origin of proteins in a pre-LUCA*, RNA-based form of life. Uncovering
the path-invariant principle then led to evidence of ladder-replicators,
together with an insight into the origin of Watson-Crick complementarity,
and that of the double-helix at the codon:anticodon interface.         

● Analogous to an invariant α-carboxyl in amino acid intermediates (tRNA
attachment site), reductive pentose-phosphate cycle intermediates
possess an invariant phosphate group. Attributing it to a pre-LUCA
polyphosphate scaffold led to evidence linking the origin of replication to
the spontaneous, pre-sugar autocatalytic formose cycle.

●  By scaling biological evolution to its physicochemical driving forces,
the nineteenth century, population-scale theory of Darwin and Wallace,
based on the principle of Malthus, could be absorbed into a more
general theory. New insights resulted, including coexistence between
competing species and driving-force induced episodic-transitions.

● Statistical correlations between peaks in photon self-interference
intensity versus reconstructed-path density corroborated a resolution of
the 'which way' problem in quantum mechanics and supported the De
Broglie-Bohm interpretation of wave-particle duality. Conservation in
continuous and discontinuous displacements has been linked to
complexity invariance at standard, relativistic, and quantum scales.

● Contribute to validating string theory as a viable theory of
quantum gravity. Offer a proof for Goldbach's conjecture and apply
number theory to information encryption.

* Pre-LUCA, pre-Last Universal Common Ancestor

Earlier contributions (1962-1982):

Norethynodrel, in birth-cotrol pill, shown to inhibit implantation (1962).

● Proposed tRNA/base-triplet binding assay to identify codon
assignments In genetic code (1963).

● Early proponent of synthetic biology (1965, 2004).

● Template sequence-complexity identified as a form of 'monomer
mixing' independent of DNA duplication thermodynamics (1965).

● Devised an immunochemical procedure to isolate specific
messenger-RNA in mouse plasmacytomas (1967).

● Initiated use of hydrogel implants for the slow-delivery of insulin,
anti-fertility agents, and other substances (1972-1974).

● Identified mammalian decapacitation factor and linked sperm fertilizing   
capacity to efflux of plasma membrane cholesterol (1971-1985).

● Fisher's fundamental theorem of natural selection shown to
apply to molecular evolution in the test tube (1978).
Site updated August 16, 2018
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A spontaneous autocatalytic reaction splits the 4-carbon
sugar (
top figure) at its C2:C3 bond (arrow), to form two
molecules of a 2-C sugar. The ancient pathways of central
metabolism conserve the imprint of a like reaction that split
the C2:C3 bond of a sugar monomer (arrow,
mid figure), in the
replication of a precursor to the RNA poly(ribose-phosphate)
scaffold. RuBP, ribulose-1,5-bis-phosphate; rf, replicative
form; PGA, 3-phospho-glycerate; [ ] marks a monomer; red,   
O atom; white, H; P and C atoms not shown. Ladder-RNA
replicator (
lower figure) with binary sequence of self-pairing
purines attached to anti-parallel (3'-5': 5'-3') ribose-phosphate
strands: A, adenosine, G, guanosine. Arrows show H-bond
donor-to-acceptor direction. Bar, 1 Å  (Davis, 2015, 2018).