Research Foundation of Southern California, La Jolla
● The Research Foundation of Southern California is a not-for-profit
scientific corporation chartered in California on February 7, 1983 by
Nelida and Brian, with help from some friends. We had each acquired
25 years of experience as research scientists in universities and
institutes in Australia, Philippines, Europe, and North America.
● Initially, the Foundation operated from a laboratory located at 10457 F
Roselle St., Sorrento Valley in San Diego. A National Institutes of
Health grant funded our research, aimed at clarifying a mammalian
mechanism regulating expression of sperm cell fertilizing capacity.
● By the mid-1980s our research had been redirected to privately funded
theoretical studies on molecular evolution in the test tube. The
physicochemical theory developed applies to the chemical processes
leading to biological evolution, making it more general than the Darwin-
Wallace model. This advance, together with our discoveries on the origin
of the genetic code, recently led to insights into the origin of replication,
including Watson-Crick complementarity in the double-helix, and origin of
life. The evidence indicates life arose with formation of the first self-
replicating, surface-bound polycarbotide - coupled to a simple, pre-sugar
autocatalytic reaction - whose monomer sequence encoded a functional
structure, promoting self-propagation. The first replicators evolved, on
theoretical grounds, in the direction that optimally damped the statistical
thermodynamic forces driving these primordial reactions.
● From 2003, Simon initiated research at the Foundation on string
theory. He also worked on number theory and information encryption.
After Brian noted that Newton’s first law of motion implied force-free
motion followed a trajectory of zero complexity, Simon extended this to
curved spaces and, together, they formulated the 'minimum complexity
principle' for dynamical processes. They subsequently linked energy
conservation to complexity-invariance in continuous and discontinuous
dynamical processes - extending Emmy Noether's theorem. Simon
published his first paper in theoretical physics at 17. He received his PhD
at 20. Prior to working with us, he was a mathematical physicist for 20
years at universities in Europe, North America, and Australia.
● Simon’s academic achievements were the subject of newspaper and
television reports. While Brian’s contributions to drug delivery
systems, sperm capacitation, synthetic biology, and genetic code have
been reported extensively. He has been a member of a number of
scientific societies, including the American Association for the
Advancement of Science, American Chemical Society, and New York
Academy of Sciences and is listed in Who’s Who in America, Who’s
Who in Science and Technology, Who’s Who in the World, and 2000
Outstanding Scientists 2008/2009.
"Life Ascending: The Ten Great Inventions of Evolution" Nick Lane, 2010
Why it (genetic code) made so little sense is a good question, addressed
by the Californian biochemist Brian K. Davis, who has a long-standing
interest in the roots of the genetic code. Davis notes that the very idea of
a "frozen accident" dispelled interest in the origins of the code: why study
an accident? Accidents just happen. Beyond that, Davis believes the
handful of researchers who retained an interest were misled by the
prevailing idea of a primordial soup. If the code originated in a soup, then
it should have its deepest roots in the molecules most likely to be
generated by the physical and chemical processes going on in the soup.
And that predicted a core of amino acids as the basis of the code, with
others being added on later. There was just enough truth in this idea for
the evidence to be tantalising, if confounding. It's only when we see the
code as the product of biosynthesis - the product of cells capable of
making their own building bocks from hydrogen and carbon dioxide -
that the patterns begin to make sense. ....
"Synthetic Life" W. Wayt Gibbs, Scientific American, May, 2004.
This advance (expansion of the genetic code) could foster developments
with inestimable biomedical potential, suggests Brian Davis of the
Research Foundation of Southern California in La Jolla. He envisions
white blood cells that could make novel proteins to destroy pathogens or
cancerous cells more quickly.
"Stop that Sperm" Gardiner Morse, Science News, June 9, 1984.
Brian Davis of the Research Foundation of Southern California reports
that microscopic membrane vesicles in the seminal plasma of various
mammals can keep rabbit sperm on hold by apparently donating
cholesterol to the sperm's membrane.
"Implantable Drug-Delivery Systems" Perry Blackshear Scientific American
By 1972 the development of a different matrix, polyacrylamide, made
possible the release of large molecules; the first report of success in this
area, involving the protein, insulin, was published by Brian K. Davis of the
Worcester Foundation for Experimental Biology.
© 2018 RFSC
Brian c. 2002
Nelida c. 2007
Simon c. 2007